Losing a single night’s sleep ‘increases diabetes risk’

Losing a single night’s sleep affects the liver’s ability to produce glucose and process insulin, increasing the risk of fatty liver disease and type 2 diabetes. The findings, which are based on mouse models, have been published in the American Journal of Physiology.

The researchers studied two groups of mice: One group was kept awake for six hours each night, while the control group was allowed to sleep as desired. The research team offered unlimited high-fat food and sugar water (mimicking lifestyle-related food choices that people make) to both groups prior to the study. During the sleep / wake period, the animals had limited opportunity for physical activity.

The researchers measured glucose levels and fat content of the liver immediately after the trial period. Blood glucose levels were significantly higher in the sleep deprivation group than controls after one six-hour session of wakefulness.

Fat levels and the production of glucose in the liver also increased in the sleep deprivation group after a single wake period. Elevated liver triglycerides are associated with insulin resistance, or the inability of the body to process insulin properly.

These findings suggest that intervention studies designed to prevent sleep deprivation-induced insulin resistance should be performed in the future.


  • Wendy

    So big risk. I was diagnosed with type 2 Diabetes and put on Metformin on June 26th, 2017. I started the some diet and followed it 100% for a few weeks and could not get my blood sugar to go below 140. Finally i began to panic and called my doctor, he told me to get used to it. He said I would be on metformin my whole life and eventually insulin. At that point i knew something wasn’t right and began to do a lot of research. Then I found Lisa’s diabetes story (google ” How Lisa freed diabetes ” ) I read that article from end to end because everything the writer was saying made absolute sense. I started the diet that day and the next week my blood sugar was down to 100 and now i have a fasting blood sugar between Mid 70’s and the 80’s. My doctor took me off the metformin after just three week of being on this lifestyle change. I have lost over 16 pounds and 3+ inches around my waist in a month. The truth is we can get off the drugs and help myself by trying natural methods

  • Bob Sleigh

    I couldn’t sleep after reading this artcle